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| COMMENTARY |
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| Year : 2022 | Volume
: 15
| Issue : 1 | Page : 121 |
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Antiphospholipid antibody syndrome and dengue fever
Viroj Wiwanitkit
Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India; Department of Tropical Medicine, Hainan Medical University, Haikou, China
| Date of Submission | 16-Sep-2020 |
| Date of Decision | 14-Oct-2020 |
| Date of Acceptance | 16-Nov-2020 |
| Date of Web Publication | 24-Jun-2021 |
Correspondence Address:
Viroj Wiwanitkit
Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/mjdrdypu.mjdrdypu_443_20
How to cite this article:
Wiwanitkit V. Antiphospholipid antibody syndrome and dengue fever. Med J DY Patil Vidyapeeth 2022;15:121 |
Dengue is an important mosquito-borne infection. This infection is a common tropical disease, and it affects millions of the world population. The disease is an acute febrile illness characterized by high fever with hemorrhagic tendency.[1] The dengue might co-exist with other medical problems, either infectious or noninfectious diseases. The report on catastrophic antiphospholipid antibody syndrome with dengue fever in Med J Dr DY Patil Univ is a good example.[2] In that case,[2] the pathogenesis is interesting, and it might be related to immunopathological process. In fact, catastrophic antiphospholipid syndrome is an important immunological disorder.[3] This immunological disorder is characterized by rapidly progressive widespread thromboses.[3] The thrombotic disorder can affect the microvasculature. The antiphospholipid antibodies are detectable.[3] This immunologic disease can cause multiorgan failure. The patient might have renal failure and respiratory failure.[3] Neurological deterioration is also observable.[3]
Infection is reported for association with catastrophic antiphospholipid syndrome.[4] A variety of infections, including viruses, bacteria, fungi, and parasites, might induce the problem.[4] The molecular mimicry is proposed as the main mechanism.[4] In dengue, molecular mimicry is an important immunopathological process. Hence, it is possible that antiphospholipid syndrome might occur in a dengue patient. Several biomolecules including antibodies, cytokines, hemostatic molecules, and viral proteins are proposed for interrelationship with thrombohemostatic alteration in dengue.[5] Pathophysiologically, transient activation of humoral immunity occurs during dengue infection, and it is a possible immunogenetic induction for coagulopathic thrombosis.[5] This pathobiological process should be the same as that of lupus storm syndrome induced by dengue.[6] As noted by Chen, antiphospholipid antibodies and increased lupus anticoagulant are related to thrombotic events in dengue patients.[7]
| References | |  |
| 1. | Wiwanitkit V. Dengue fever: Diagnosis and treatment. Expert Rev Anti Infect Ther 2010;8:841-5.  |
| 2. | Khanna A, Periwal P, Talwar D. Double trouble - Catastrophic antiphospholipid antibody syndrome with dengue fever. doi: 10.4103/mjdrdypu.mjdrdypu_408_20. |
| 3. | Costedoat-Chalumeau N, Coutte L, Le Guern V, Morel N, Leroux G, Paule R, et al. 2016 review on catastrophic antiphospholipid syndrome. Presse Med 2016;45:1084-92. |
| 4. | Mendoza-Pinto C, García-Carrasco M, Cervera R. Role of infectious diseases in the antiphospholipid syndrome (including its catastrophic variant). Curr Rheumatol Rep 2018;20:62. |
| 5. | Chuang YC, Lin YS, Liu CC, Liu HS, Liao SH, Shi MD, et al. Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection. J Formos Med Assoc 2013;112:12-7. |
| 6. | Sandro O, Ana Cristina J, Marcelo F, Carlos M, Fabio D, Fernanda G. 1155 poster: dengue fever causing lupus storm syndrome in ICU. Crit Care Med 2012;40:1-328. |
| 7. | Chen WH. An unusual transitory increase of lupus anticoagulant in dengue virus infection complicated with cerebral ischaemia. J Infect 2006;52:e87-91. |
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