Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Print this page Email this page Users Online: 6562

  Table of Contents  
Year : 2022  |  Volume : 15  |  Issue : 1  |  Page : 121  

Antiphospholipid antibody syndrome and dengue fever

Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India; Department of Tropical Medicine, Hainan Medical University, Haikou, China

Date of Submission16-Sep-2020
Date of Decision14-Oct-2020
Date of Acceptance16-Nov-2020
Date of Web Publication24-Jun-2021

Correspondence Address:
Viroj Wiwanitkit
Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra

Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mjdrdypu.mjdrdypu_443_20

Rights and Permissions

How to cite this article:
Wiwanitkit V. Antiphospholipid antibody syndrome and dengue fever. Med J DY Patil Vidyapeeth 2022;15:121

How to cite this URL:
Wiwanitkit V. Antiphospholipid antibody syndrome and dengue fever. Med J DY Patil Vidyapeeth [serial online] 2022 [cited 2022 Aug 11];15:121. Available from: https://www.mjdrdypv.org/text.asp?2022/15/1/121/319304

Dengue is an important mosquito-borne infection. This infection is a common tropical disease, and it affects millions of the world population. The disease is an acute febrile illness characterized by high fever with hemorrhagic tendency.[1] The dengue might co-exist with other medical problems, either infectious or noninfectious diseases. The report on catastrophic antiphospholipid antibody syndrome with dengue fever in Med J Dr DY Patil Univ is a good example.[2] In that case,[2] the pathogenesis is interesting, and it might be related to immunopathological process. In fact, catastrophic antiphospholipid syndrome is an important immunological disorder.[3] This immunological disorder is characterized by rapidly progressive widespread thromboses.[3] The thrombotic disorder can affect the microvasculature. The antiphospholipid antibodies are detectable.[3] This immunologic disease can cause multiorgan failure. The patient might have renal failure and respiratory failure.[3] Neurological deterioration is also observable.[3]

Infection is reported for association with catastrophic antiphospholipid syndrome.[4] A variety of infections, including viruses, bacteria, fungi, and parasites, might induce the problem.[4] The molecular mimicry is proposed as the main mechanism.[4] In dengue, molecular mimicry is an important immunopathological process. Hence, it is possible that antiphospholipid syndrome might occur in a dengue patient. Several biomolecules including antibodies, cytokines, hemostatic molecules, and viral proteins are proposed for interrelationship with thrombohemostatic alteration in dengue.[5] Pathophysiologically, transient activation of humoral immunity occurs during dengue infection, and it is a possible immunogenetic induction for coagulopathic thrombosis.[5] This pathobiological process should be the same as that of lupus storm syndrome induced by dengue.[6] As noted by Chen, antiphospholipid antibodies and increased lupus anticoagulant are related to thrombotic events in dengue patients.[7]

  References Top

Wiwanitkit V. Dengue fever: Diagnosis and treatment. Expert Rev Anti Infect Ther 2010;8:841-5.  Back to cited text no. 1
Khanna A, Periwal P, Talwar D. Double trouble - Catastrophic antiphospholipid antibody syndrome with dengue fever. doi: 10.4103/mjdrdypu.mjdrdypu_408_20.  Back to cited text no. 2
Costedoat-Chalumeau N, Coutte L, Le Guern V, Morel N, Leroux G, Paule R, et al. 2016 review on catastrophic antiphospholipid syndrome. Presse Med 2016;45:1084-92.  Back to cited text no. 3
Mendoza-Pinto C, García-Carrasco M, Cervera R. Role of infectious diseases in the antiphospholipid syndrome (including its catastrophic variant). Curr Rheumatol Rep 2018;20:62.  Back to cited text no. 4
Chuang YC, Lin YS, Liu CC, Liu HS, Liao SH, Shi MD, et al. Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection. J Formos Med Assoc 2013;112:12-7.  Back to cited text no. 5
Sandro O, Ana Cristina J, Marcelo F, Carlos M, Fabio D, Fernanda G. 1155 poster: dengue fever causing lupus storm syndrome in ICU. Crit Care Med 2012;40:1-328.  Back to cited text no. 6
Chen WH. An unusual transitory increase of lupus anticoagulant in dengue virus infection complicated with cerebral ischaemia. J Infect 2006;52:e87-91.  Back to cited text no. 7


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article

 Article Access Statistics
    PDF Downloaded33    
    Comments [Add]    

Recommend this journal