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Antiphospholipid antibody syndrome and dengue fever


 Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India; Department of Tropical Medicine, Hainan Medical University, Haikou, China

Date of Submission16-Sep-2020
Date of Decision14-Oct-2020
Date of Acceptance16-Nov-2020

Correspondence Address:
Viroj Wiwanitkit,
Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mjdrdypu.mjdrdypu_443_20



How to cite this URL:
Wiwanitkit V. Antiphospholipid antibody syndrome and dengue fever. Med J DY Patil Vidyapeeth [Epub ahead of print] [cited 2021 Dec 6]. Available from: https://www.mjdrdypv.org/preprintarticle.asp?id=319304



Dengue is an important mosquito-borne infection. This infection is a common tropical disease, and it affects millions of the world population. The disease is an acute febrile illness characterized by high fever with hemorrhagic tendency.[1] The dengue might co-exist with other medical problems, either infectious or noninfectious diseases. The report on catastrophic antiphospholipid antibody syndrome with dengue fever in Med J Dr DY Patil Univ is a good example.[2] In that case,[2] the pathogenesis is interesting, and it might be related to immunopathological process. In fact, catastrophic antiphospholipid syndrome is an important immunological disorder.[3] This immunological disorder is characterized by rapidly progressive widespread thromboses.[3] The thrombotic disorder can affect the microvasculature. The antiphospholipid antibodies are detectable.[3] This immunologic disease can cause multiorgan failure. The patient might have renal failure and respiratory failure.[3] Neurological deterioration is also observable.[3]

Infection is reported for association with catastrophic antiphospholipid syndrome.[4] A variety of infections, including viruses, bacteria, fungi, and parasites, might induce the problem.[4] The molecular mimicry is proposed as the main mechanism.[4] In dengue, molecular mimicry is an important immunopathological process. Hence, it is possible that antiphospholipid syndrome might occur in a dengue patient. Several biomolecules including antibodies, cytokines, hemostatic molecules, and viral proteins are proposed for interrelationship with thrombohemostatic alteration in dengue.[5] Pathophysiologically, transient activation of humoral immunity occurs during dengue infection, and it is a possible immunogenetic induction for coagulopathic thrombosis.[5] This pathobiological process should be the same as that of lupus storm syndrome induced by dengue.[6] As noted by Chen, antiphospholipid antibodies and increased lupus anticoagulant are related to thrombotic events in dengue patients.[7]



 
  References Top

1.
Wiwanitkit V. Dengue fever: Diagnosis and treatment. Expert Rev Anti Infect Ther 2010;8:841-5.  Back to cited text no. 1
    
2.
Khanna A, Periwal P, Talwar D. Double trouble - Catastrophic antiphospholipid antibody syndrome with dengue fever. doi: 10.4103/mjdrdypu.mjdrdypu_408_20.  Back to cited text no. 2
    
3.
Costedoat-Chalumeau N, Coutte L, Le Guern V, Morel N, Leroux G, Paule R, et al. 2016 review on catastrophic antiphospholipid syndrome. Presse Med 2016;45:1084-92.  Back to cited text no. 3
    
4.
Mendoza-Pinto C, García-Carrasco M, Cervera R. Role of infectious diseases in the antiphospholipid syndrome (including its catastrophic variant). Curr Rheumatol Rep 2018;20:62.  Back to cited text no. 4
    
5.
Chuang YC, Lin YS, Liu CC, Liu HS, Liao SH, Shi MD, et al. Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection. J Formos Med Assoc 2013;112:12-7.  Back to cited text no. 5
    
6.
Sandro O, Ana Cristina J, Marcelo F, Carlos M, Fabio D, Fernanda G. 1155 poster: dengue fever causing lupus storm syndrome in ICU. Crit Care Med 2012;40:1-328.  Back to cited text no. 6
    
7.
Chen WH. An unusual transitory increase of lupus anticoagulant in dengue virus infection complicated with cerebral ischaemia. J Infect 2006;52:e87-91.  Back to cited text no. 7
    




 

 
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