Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Print this page Email this page Users Online: 197
Ahead of Print

Histopathology of gastroesophageal lesions and its correlation with Helicobacter pylori and mucin histochemistry

 Department of Pathology, Government Medical College, Nagpur, Maharashtra, India

Correspondence Address:
Anupama Praveen Gupta,
203, Shyam Dham, C. A. Road, Babulban, Nagpur - 440 008, Maharashtra
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mjdrdypu.mjdrdypu_82_20

Objective: Helicobacter pylori infection and subsequent gastric atrophy and intestinal metaplasia (IM) are postulated to increase incidence of gastroesophageal cancers. Hence, this study was carried out with objective to study histomorphology of gastroesophageal lesions and correlate with H. pylori and mucin histochemistry. Materials and Methods: This is an observational, prospective study on 120 gastroesophageal biopsies for identification of H. pylori and mucin histochemistry for type of metaplasia in addition to routine histopathology. Results: Of 120 gastroesophageal biopsies, 58 were esophageal and 62 gastric. Various esophageal lesions comprised of esophagitis, Barrett's esophagus, dysplasia, and esophageal malignancies. H. pylori were detected in 1, 4, and 1 cases of esophagitis, Barrett's esophagus, and adenosquamous carcinoma, respectively. IM was seen in 2 cases of Barrett's esophagus and one each of adenocarcinoma and adenosquamous carcinoma of esophagus. Gastric pathologies comprised of chronic gastritis, gastric ulcer, hyperplastic polyp, Peutz–Jeghers syndrome, adenocarcinoma, and gastrointestinal stromal tumor. A study for H. pylori and mucin histochemistry revealed statistically significant association between H. pylori and gastric adenocarcinoma, chronic gastritis but not with gastric ulcer. 76.31% and 21.73% cases of adenocarcinoma and gastric nonneoplastic lesions showed IM with statistically significant association with gastric adenocarcinoma particularly intestinal type. Conclusion: Since there is significant role of H. pylori and gastroesophageal malignancies histopathology and early detection of the bacilli can help in timely treatment and prevention of gastroesophageal malignancy.

Print this article
  Search Pubmed for
    -  Gupta AP
    -  Suryawanshi UD
    -  Kumbhalkar DT
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded3    

Recommend this journal