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Spectrum of cervical epithelial abnormalities in immune surveillance patients and its association with CD4 count

1 Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India
2 Department of Community Medicine, Armed Forces Medical College, Pune, Maharashtra, India

Correspondence Address:
Arun Kumar Yadav,
Department of Community Medicine, Armed Forces Medical College, Pune - 411 040, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mjdrdypu.mjdrdypu_56_21

Background: Cervical cancer is the fourth most common cancer worldwide. It is well-known that cervical carcinoma progresses from a preinvasive disease, which can be picked up easily by routine cervical smear examination. Studies have shown that dysplasia is five times more common in females with human immunodeficiency virus (HIV) than in healthy controls. This study aimed to find if any association existed between CD4 count, viral load, parity, hemoglobin level, age at first childbirth, duration of highly active antiretroviral therapy, and cervical epithelial abnormalities. Methods: The present study was a 4-year retrospective study conducted in the Department of Pathology at a tertiary care hospital of Western Maharashtra. The liquid-based Pap smear slides of HIV patients reported during the period were retrieved and reviewed. The data collected were tabulated and analyzed using the SPSS software. Statistical test was used to find an association between various clinicopathological variables and smear findings. Results: Pap smear abnormalities were found in 14% of the patients. The present study found a statistically significant association between Pap smear abnormalities and CD4 count, viral load, and the hemoglobin level of the patient. Conclusion: There is a high prevalence of Pap smear abnormalities in HIV-positive patients. CD4 count, hemoglobin level, and viral load can be used as surrogate markers for deciding the frequency of Pap smear in HIV patients.

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