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Utility of morphometry in breast carcinoma and its correlation with grade and MIB-1 labelling index


1 Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India
2 Department of Community Medicine, Armed Forces Medical College, Pune, Maharashtra, India

Correspondence Address:
Puneet Baveja,
Armed Forces Medical College, Pune - 411 040, Maharashtra
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mjdrdypu.mjdrdypu_234_21

Introduction: Breast cancer is the leading cancer in women worldwide. In breast cancer, measurement of nuclear proliferation can be used in conjunction with other tumor parameters such as grade, lymphovascular invasion, and nodal status for prognosis. Various techniques have been developed to study the proliferation rate using immunohistochemistry (IHC) with Ki67/MIB-1. Employing morphometry has been reported to add accuracy to proliferation counts. The present study was done with an aim to study the pattern of MIB-1 labeling index by morphometry. Methodology: This is a descriptive study carried out at a tertiary care center in Western Maharashtra over a period of 18 months wherein 94 cases were studied. Maximum infiltrating tumor was assessed on H and E-stained sections. MIB-1% was determined using IHC and nuclear size was determined using morphometry. Results: There was a weak correlation between MIB-1 index (%) of Grade 1 tumors and their average nuclear sizes which were not significant (P = 0.509) whereas the correlation between MIB-1 index of Grade 2 and 3 tumors and their average nuclear sizes had a strong correlation with P < 0.05. Overall, it was seen that MIB-1 (%) index and nuclear sizes had a strong correlation with P < 0.05. Conclusions: MIB-1 labeling index significantly correlated with the average nuclear size of the tumor and MIB-1 labeling index can serve as a useful adjunct to histological grading of the tumors. In patients with a low histological Grade but high MIB-1 labeling index suggesting a poorer prognosis, caution may be exercised with an aggressive line of management.


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