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Inducible resistance to clindamycin in staphylococcus aureus and methicillin-resistant staphylococcus aureus isolated from clinical samples in tertiary care hospitals in Guwahati City


1 Department of Biotechnology, Faculty of Science Assam Downtown University, Guwahati, India
2 Research Cell, Assam Downtown University, Guwahati, India
3 Research Cell, Central India Institute of Medical Science, Nagpur, India

Correspondence Address:
Minakshi Bhattacharjee,
Associate Professor, Department of Biotechnology, Assam
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mjdrdypu.mjdrdypu_172_21

Background: Methicillin-resistant staphylococcus aureus (MRSA) are responsible for many hospital-acquired infections. Clindamycin (CL) is used to treat methicillin-sensitive S. aureus (MSSA) and MRSA. Antibiotic sensitivity testing (AST) can miss out the inducible CL resistance (CL-R) and result in failure of treatment. D-test detects inducible CL-R. Subjects and Methods: One hundred and ten S. aureus strains were tested. D-test was performed using erythromycin (ER) (15 mcg) and CL (2 mcg). The absence of inhibition around ER and a zone of inhibition around CL with flattening of the zone facing ER side is taken as positive D-test. Results: Of the total S. aureus strains, 36% were MRSA and 74% were MSSA. A total of 20 (18.18%) strains out of 110 were found to have inducible CL-R. In this study, MRSA (19.4%) were found to have higher percentage of D-test positivity as compared to MSSA (17.56%). Conclusion: D-test must be performed routinely as a part of AST for the presence of inducible phenotype.


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    -  Bhattacharjee M
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