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Role of p53 and Her2/Neu as a prognostic biomarker in breast carcinoma

1 Senior resident, Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India
2 Associate Professor, Department of Pathology, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, Maharashtra, India
3 Dean, Director and Professor, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, Maharashtra, India

Correspondence Address:
Nitin M Gangane,
Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha - 442 102, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mjdrdypu.mjdrdypu_187_21

Introduction: The purpose of this study is to determine if p53 and Her2/neu have prognostic value in recognizing more aggressive behavior and low prognostic breast cancer. p53 is involved in regulating cell proliferation-inducing apoptosis and enhancing chromosomal stability. In carcinogenesis, disturbance of these roles tends to play significant role. There is evidence that overexpression of Her2 and p53 is implicated in the development of breast cancer. Her2 (c-erbB2) encodes a membrane protein (p185) that, after interaction with its ligands, is phosphorylated by tyrosine. Overexpression of Her2 occurs by either gene amplification or by overexpression of mRNA. Materials and Methods: Fifty consecutive diagnosed cases of infiltrating duct carcinoma over a period of 2 years were reviewed from archived pathology records. Evaluation of p53 and Her2/neu staining was analyzed and staining was scored. Results: p53 and Her2/neu were both positive in 14% of cases, both were negative in 24% of cases. p53 positivity with Her2/neu negativity was seen in 52% of cases, whereas p53 negativity and Her2/neu positivity were seen in 10% of cases. Follow-up was available in 21 cases, and survival pattern of patients according to various clinicopathological parameters was done. Conclusion: A well-defined cutoff to label p53 overexpression will help in ascertaining the role of p53 as a prognostic marker. Her2/neu overexpression is associated with lymph node involvement.

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