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A rare case of Marchiafava Bignami disease


 Department of General Medicine, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D Y Patil Vidyapeeth, Pimpri, Pune, Maharashtra, India

Correspondence Address:
Vikram B Vikhe,
Department of General Medicine, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D Y Patil Vidyapeeth, Pimpri, Pune - 411 018, Maharashtra
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mjdrdypu.mjdrdypu_659_21

Marchiafava-Bignami disease (MBD) is a rare neurodegenerative disorder affecting the corpus callosum. It is usually seen in chronic alcoholics. MBD is an alcohol-associated disorder characterized by demyelination and necrosis of the corpus callosum. MBD was initially described in wine drinkers. It was considered to be either due to the toxic effect of alcohol or due to nutritional deficiency. Modern imaging techniques like MRI helps in the early detection of MBD even in the absence of classical clinical symptoms. WE report a case of chronic alcoholism since 20 years who presented to us with clinical signs of disorientation, dysarthria, behavioral symptoms, irrelevant talk, lapses in memory, sensory ataxia, and MRI findings suggestive of demyelination and subsequent atrophy of corpus callosum.


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    -  Vikhe VB
    -  Chopda KM
    -  Ahmed J
    -  Khaladkar S
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