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LETTER TO THE EDITOR
Ahead of print publication  

Thyroid profile in idiopathic childhood steroid-sensitive nephrotic syndrome


 Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq

Date of Submission24-Dec-2021
Date of Decision10-Feb-2022
Date of Acceptance21-Mar-2022

Correspondence Address:
Mahmood D Al-Mendalawi,
P.O. Box 55302, Baghdad Post Office, Baghdad
Iraq
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mjdrdypu.mjdrdypu_1022_21



How to cite this URL:
Al-Mendalawi MD. Thyroid profile in idiopathic childhood steroid-sensitive nephrotic syndrome. Med J DY Patil Vidyapeeth [Epub ahead of print] [cited 2022 Dec 7]. Available from: https://www.mjdrdypv.org/preprintarticle.asp?id=346441



Sir,

In the November-December 2021 issue of the Medical Journal of Dr. D.Y. Patil Vidyapeeth, Nandi et al.[1] studied thyroid status in a cohort of Indian children with steroid-sensitive nephrotic syndrome (NS) during the time of relapse and remission. They found that the levels of thyroid stimulating-hormone (TSH), triiodothyronine (T3), and thyroxine (T4) significantly varied at the attack/relapse compared to at remission. While T3 and T4 levels stayed within the normal ranges, there was a rise in the TSH level at the time of the attack/relapse.[1] Apart from the few study limitations presented by Nandi et al.,[1] we believe that the following limitation is relevant. The accurate evaluation of thyroid gland functions for a given pediatric population requires the need to refer to the thyroid hormones normative values (THNV). As THNV are determined by different factors such as age, gender, weight, and ethnicity,[2] certain pediatric populations-specific THNV have been generated.[3],[4] India has already constructed THNV for each year of life for both genders separately to be utilized in the clinical fields and researches centers.[5] In the study, methodology, Nandi et al.[1] regrettably did not address which THNV they referred to assess thyroid condition in the studied cohort. This methodological limitation might throw further suspicions on the study findings.

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Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Nandi M, Basu B, Tarai A, Sar T. Thyroid profile in idiopathic childhood steroid-sensitive nephrotic syndrome. Med J DY Patil Vidyapeeth 2021;14:637-41.  Back to cited text no. 1
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2.
Önsesveren I, Barjaktarovic M, Chaker L, de Rijke YB, Jaddoe VWV, van Santen HM, et al. Childhood thyroid function reference ranges and determinants: A literature overview and a prospective cohort study. Thyroid 2017;27:1360-9.  Back to cited text no. 2
    
3.
Gunapalasingham G, Frithioff-Bøjsøe C, Lund MAV, Hedley PL, Fonvig CE, Dahl M, et al. Reference values for fasting serum concentrations of thyroid-stimulating hormone and thyroid hormones in healthy Danish/North-European white children and adolescents. Scand J Clin Lab Invest 2019;79:129-35.  Back to cited text no. 3
    
4.
Argente Del Castillo P, Pastor García MI, Morell-Garcia D, Martinez-Gomez L, Ballesteros MA, Barcelo A. Thyroid panel reference intervals in healthy children and adolescents: A Spanish cohort. Clin Biochem 2021;91:39-44.  Back to cited text no. 4
    
5.
Marwaha RK, Tandon N, Desai AK, Kanwar R, Aggarwal R, Sastry A, et al. Reference range of thyroid hormones in healthy school-age children: Country-wide data from India. Clin Biochem 2010;43:51-6.  Back to cited text no. 5
    




 

 
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